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1

Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis

Diana Lindberg, Mario de la Fuente Revenga, Mikael Widersten

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 154 KB

english, 2010

2

Stereoselective Oxidation of Aryl-Substituted Vicinal Diols into Chiral α-Hydroxy Aldehydes by Re-Engineered Propanediol Oxidoreductase

Blikstad, Cecilia, Dahlström, Käthe M., Salminen, Tiina A., Widersten, Mikael

Journal:

Year:

2013

Language:

english

File:

PDF, 4.30 MB

english, 2013

3

New Stereoselective Biocatalysts for Carboligation and Retro-Aldol Cleavage Reaction Derived from D-Fructose 6-Phosphate Aldolase

Ma, Huan, Engel, Sarah, Enugala, Thilak Reddy, Al-Smadi, Derar, Gautier, Candice, Widersten, Mikael

Journal:

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

4

Modification of Substrate Specificity Resulting in an Epoxide Hydrolase with Shifted Enantiopreference for (2,3-Epoxypropyl)benzene

Ann Gurell, Mikael Widersten

Journal:

Year:

2010

Language:

english

File:

PDF, 410 KB

english, 2010

5

Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance

Stanley Mukanganyama, Mikael Widersten, Yogeshkumar S. Naik, Bengt Mannervik, Julia A. Hasler

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 123 KB

english, 2002

6

The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an ‘orphaned’ epoxide hydrolase

Lisa T. Elfström, Mikael Widersten

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2005

Language:

english

File:

PDF, 461 KB

english, 2005

7

Substrate-dependent hysteretic behavior in StEH1-catalyzed hydrolysis of styrene oxide derivatives

Diana Lindberg, Adolf Gogoll, Mikael Widersten

Journal:

Year:

2008

Language:

english

File:

PDF, 386 KB

english, 2008

8

Removal of distal protein–water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability

Ann Thomaeus, Agata Naworyta, Sherry L. Mowbray, Mikael Widersten

Journal:

Protein Science

Year:

2008

Language:

english

File:

PDF, 498 KB

english, 2008

9

X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes

Sherry L. Mowbray, Lisa T. Elfström, Kerstin M. Ahlgren, C. Evalena Andersson, Mikael Widersten

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 915 KB

english, 2006

10

Structural determinants in domain II of human glutathione transferase M2–2 govern the characteristic activities with aminochrome, 2-cyano-1, 3-dimethyl-1-nitrosoguanidine, and 1, 2-dichloro-4-nitrobenzene

Lars O. Hansson, Mikael Widersten, Bengt Mannervik, Robyn Bolton-Grob

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 439 KB

english, 1999

11

Mechanism-Based Phage Display Selection of Active-Site Mutants of Human Glutathione Transferase A1-1 Catalyzing SNAr Reactions†

Hansson, Lars O., Widersten, Mikael, Mannervik, Bengt

Journal:

Year:

1997

Language:

english

File:

PDF, 314 KB

english, 1997

12

One-step enzyme extraction and immobilization for biocatalysis applications

Karim Engelmark Cassimjee, Robert Kourist, Diana Lindberg, Marianne Wittrup Larsen, Nguyen Hong Thanh, Mikael Widersten, Uwe T. Bornscheuer, Professor Per Berglund

Journal:

Biotechnology Journal

Year:

2011

Language:

english

File:

PDF, 180 KB

english, 2011

13

Functional characterization of a stereospecific diol dehydrogenase, FucO, from Escherichia coli: Substrate specificity, pH dependence, kinetic isotope effects and influence of solvent viscosity

Cecilia Blikstad, Mikael Widersten

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2010

Language:

english

File:

PDF, 363 KB

english, 2010

14

Preface

Bengt Mannervik, R. Morgenstern, Gun Stenberg, Mikael Widersten

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

15

Hydrophobic sequences can substitute for the wild-type N-terminal sequence of cystatin A (stefin A) in tight binding to cysteine proteinases : Selection of high-affinity N-terminal region variants by phage display

Karin Ylinenjärvi, Mikael Widersten, Ingemar Björk

Journal:

Year:

1999

Language:

english

File:

PDF, 372 KB

english, 1999

16

Glutathione Transferases with Novel Active Sites Isolated by Phage Display from a Library of Random Mutants

Mikael Widersten, Bengt Mannervik

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 629 KB

english, 1995

17

Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105

Ann-Sofie Johansson, Gun Stenberg, Mikael Widersten, Bengt Mannervik

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 300 KB

english, 1998

18

Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library

Fanyi Jiang, Susanne Wisén, Mikael Widersten, Birgitta Bergman, Bengt Mannervik

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 340 KB

english, 2000

19

Optimized Heterologous Expression of the Polymorphic Human Glutathione Transferase M1-1 Based on Silent Mutations in the Corresponding cDNA

Mikael Widersten, Mao Huang, Bengt Mannervik

Journal:

Protein Expression and Purification

Year:

1996

Language:

english

File:

PDF, 137 KB

english, 1996

20

Heterologous Expression inEscherichia coliof Soluble Active-Site Random Mutants of Haloalkane Dehalogenase fromXanthobacter autotrophicusGJ10 by Coexpression of Molecular Chaperonins GroEL/ES

Mikael Widersten

Journal:

Protein Expression and Purification

Year:

1998

Language:

english

File:

PDF, 187 KB

english, 1998

21

Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a

Mikael Widersten, Eva Holmström, Bengt Mannervik

Journal:

Year:

1991

Language:

english

File:

PDF, 416 KB

english, 1991

22

Mutations in salt-bridging residues at the interface of the core and lid domains of epoxide hydrolase StEH1 affect regioselectivity, protein stability and hysteresis

Diana Lindberg, Shabbir Ahmad, Mikael Widersten

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

23

Structure–function relationships of epoxide hydrolases and their potential use in biocatalysis

Mikael Widersten, Ann Gurell, Diana Lindberg

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 1.30 MB

english, 2010

24

Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics

Sandra Eklund, Ann-Christin Lindås, Emil Hamnevik, Mikael Widersten, Birgitta Tomkinson

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2012

Language:

english

File:

PDF, 1.71 MB

english, 2012

25

Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1

Robert Björnestedt, Gun Stenberg, Mikael Widersten, Philip G. Board, Irmgard Sinning, T. Alwyn Jones, Bengt Mannervik

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 953 KB

english, 1995

26

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

Sundberg, Kathrin, Widersten, Mikael, Seidel, Albrecht, Mannervik, Bengt, Jernström, Bengt

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

27

Kinetic characterization of Rhodococcus ruber DSM 44541 alcohol dehydrogenase A

Hamnevik, Emil, Blikstad, Cecilia, Norrehed, Sara, Widersten, Mikael

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2014

Language:

english

File:

PDF, 1.89 MB

english, 2014

28

Protein engineering for development of new hydrolytic biocatalysts

Widersten, Mikael

Journal:

Current Opinion in Chemical Biology

Year:

2014

Language:

english

File:

PDF, 460 KB

english, 2014

29

Implications for an Ionized Alkyl-Enzyme Intermediate during StEH1-Catalyzed trans -Stilbene Oxide Hydrolysis †

Elfström, Lisa T., Widersten, Mikael

Journal:

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

30

Temperature and pH Dependence of Enzyme-Catalyzed Hydrolysis of trans -Methylstyrene Oxide. A Unifying Kinetic Model for Observed Hysteresis, Cooperativity, and Regioselectivity

Lindberg, Diana, de la Fuente Revenga, Mario, Widersten, Mikael

Journal:

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

31

Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1

Widersten, Mikael, Bjoernestedt, Robert, Mannervik, Bengt

Journal:

Year:

1994

Language:

english

File:

PDF, 876 KB

english, 1994

32

Involvement of the Carboxyl Groups of Glutathione in the Catalytic Mechanism of Human Glutathione Transferase A1-1 †

Widersten, Mikael, Björnestedt, Robert, Mannervik, Bengt

Journal:

Year:

1996

Language:

english

File:

PDF, 545 KB

english, 1996

33

Chlorine Kinetic Isotope Effects on the Haloalkane Dehalogenase Reaction

Lewandowicz, Andrzej, Rudziński, Juliusz, Tronstad, Lisa, Widersten, Mikael, Ryberg, Per, Matsson, Olle, Paneth, Piotr

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

34

Obtaining Optical Purity for Product Diols in Enzyme-Catalyzed Epoxide Hydrolysis: Contributions from Changes in both Enantio- and Regioselectivity

Carlsson, Åsa Janfalk, Bauer, Paul, Ma, Huan, Widersten, Mikael

Journal:

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

35

Conjugation of Highly Reactive Aflatoxin B 1exo- 8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters †

Johnson, William W., Ueng, Yune-Fang, Widersten, Mikael, Mannervik, Bengt, Hayes, John D., Sherratt, Philip J., Ketterer, Brian, Guengerich, F. Peter

Journal:

Year:

1997

Language:

english

File:

PDF, 154 KB

english, 1997

36

Active Site of Epoxide Hydrolases Revisited: A Noncanonical Residue in Potato StEH1 Promotes both Formation and Breakdown of the Alkylenzyme Intermediate †

Thomaeus, Ann, Carlsson, Jens, Åqvist, Johan, Widersten, Mikael

Journal:

Year:

2007

Language:

english

File:

PDF, 444 KB

english, 2007

37

Repertoire Selection of Variant Single-Chain Cro: Toward Directed DNA-Binding Specificity of Helix−Turn−Helix Proteins †

Nilsson, Mikael T. I., Widersten, Mikael

Journal:

Year:

2004

Language:

english

File:

PDF, 295 KB

english, 2004

38

Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution

Blikstad, Cecilia, Dahlström, Käthe M., Salminen, Tiina A., Widersten, Mikael

Journal:

Year:

2014

Language:

english

File:

PDF, 992 KB

english, 2014

39

Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

Chaga, Grigoriy, Widersten, Mikael, Andersson, Lennart, Porath, Jerker, Danielson, U.Helena, Mannervik, Bengt

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 1.94 MB

english, 1994

40

Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes

Castro, Victor M., Söderström, Mats, Carlberg, Inger, Widersten, Mikael, Platz, Anton, Mannervik, Bengt

Journal:

Year:

1990

Language:

english

File:

PDF, 3.64 MB

english, 1990

41

A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes

Widersten, Mikael, Mannervik, Bengt

Journal:

Protein Engineering Design and Selection

Year:

1992

Language:

english

File:

PDF, 1.69 MB

english, 1992

42

Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes

Amrein, Beat Anton, Bauer, Paul, Duarte, Fernanda, Janfalk Carlsson, Åsa, Naworyta, Agata, Mowbray, Sherry L., Widersten, Mikael, Kamerlin, Shina C. L.

Journal:

Year:

2015

Language:

english

File:

PDF, 9.57 MB

english, 2015

43

Detoxication of Base Propenals and Other α,β-Unsaturated Aldehyde Products of Radical Reactions and Lipid Peroxidation by Human Glutathione Transferases

Kiflu Berhane, Mikael Widersten, Ake Engstrom, John W. Kozarich and Bengt Mannervik

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 962 KB

english, 1994

44

Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

Ma, Huan, Szeler, Klaudia, Kamerlin, Shina C. L., Widersten, Mikael

Journal:

Chemical Science

Year:

2016

Language:

english

File:

PDF, 1.56 MB

english, 2016

45

Proposed reductive metabolism of artemisinin by glutathione transferases in vitro

Mukanganyama, Stanley, Naik, Yogeshkumar S., Widersten, Mikael, Mannervik, Bengt, Hasler, Julia A.

Journal:

Free Radical Research

Year:

2001

Language:

english

File:

PDF, 717 KB

english, 2001

46

Correction to Obtaining Optical Purity for Product Diols in Enzyme-Catalyzed Epoxide Hydrolysis: Contributions from Changes in both Enantio- and Regioselectivity

Janfalk Carlsson, Åsa, Bauer, Paul, Ma, Huan, Widersten, Mikael

Journal:

Year:

2016

Language:

english

File:

PDF, 501 KB

english, 2016

47

A Microplate Format Assay for Real-Time Screening for New Aldolases that Accept Aryl-Substituted Acceptor Substrates

Ma, Huan, Enugala, Thilak Reddy, Widersten, Mikael

Journal:

Year:

2015

Language:

english

File:

PDF, 353 KB

english, 2015

48

Laboratory-Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis

Janfalk Carlsson, Åsa, Bauer, Paul, Dobritzsch, Doreen, Nilsson, Mikael, Kamerlin, S. C. Lynn, Widersten, Mikael

Journal:

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

49

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

BAEZ, Sofia, SEGURA-AGUILAR, Juan, WIDERSTEN, Mikael, JOHANSSON, Ann-Sofie, MANNERVIK, Bengt

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 225 KB

english, 1997

50

An approach to optimizing the active site in a glutathione transferase by evolution in vitro

HANSSON, Lars O., WIDERSTEN, Mikael, MANNERVIK, Bengt

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 179 KB

english, 1999

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